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Regenerative Rejuvenation of Ageing Skin and Its Mechanism

---Edited according to the audio record of the lecture of Prof. XU Rong-xiang delivered on April 22^nd, 2013

Foreword
Since ancient times, ageing has long been a tough task that seems unable to be tackled by human beings. The essence of ageing is the gradual degeneration of anatomical structure and physiological functions of various tissues and organs, which eventually results in termination of life. This is the law of nature. Human beings have ever tried to fight against the natural law, and the life science community has devoted huge amount of energy and efforts into the attempts, such as modifying genes and creating new species and etc., to delay the process of ageing. However, all these efforts seemed unsuccessful when James Watson, the most renowned life scientist in the 20th century and “Father of Genetics”, declared negation of gene therapy. It tells us that all hypotheses without the confirmation of actual results should be regarded as scientific exploration rather than truth. In contrast, our Human Body Regenerative Restoration Science (HBRRS) is based on the scientific results, following the principle of conforming to the attributes of life. By taking advantage of the potentials of human body regeneration and exogenous regenerative nutrients, our science studies the regenerative potentials of cells in our body and the regenerative nutrients in order to regenerate tissues and organs in situ to resolve such problems as acquired defects, premature aging, degeneration, serious diseases and premature apoptosis, thus protecting normal physiological structures and functions of body tissues and organs to realize the goal of preventing and curing diseases, preventing and terminating premature aging, and regenerating and restoring in situ the prematurely ageing tissues and organs. It is currently the only science that can cease the aging process and achieve the regenerative restoration and rejuvenation of organs and the human body. More importantly, it is the only true science confirmed by scientific results, serving as the only scientific truth in life science circle. Under this scientific system, we accomplished the regenerative rejuvenation of skin - the largest organ of the human body, which is just one of our scientific achievements. This lecture is a review on the mechanism of the achievement.

Transcript

Hello, everybody! Today, I would like to talk about the mechanism of ageing skin regenerative rejuvenation.

I think all of you are basically familiar with the mechanism. But, in practical application, when we rejuvenate ageing skin, whether you can spontaneously refer to this scientific concept and mechanism is a prerequisite. Let’s take the experimental project of skin regenerative rejuvenation as an example. What is the true mechanism? Herein, I’d like to emphasize that you can not be ambiguous or make up a story when elaborating the mechanism; it must be true in science itself. How to present the true mechanism is the core content of today’s lecture and the necessary qualification of scientific researchers as well. As a professional technician, every one of you should understand and bear in mind this. Then, how should we present our mechanism? It’s very simple. We’re trying to state the truth, not to review some opinions. This is the focus. And, with this focus, I’m going to deliver a lecture on “The Mechanism of Ageing Skin Regenerative Rejuvenation” today.

Part One

How to accurately understand and elaborate a scientific truth?

The mechanism of skin regenerative rejuvenation originates from the core mechanism of HBRRS. Then, what is the “core mechanism” of HBRRS? The PRCs (potential regenerative cells) in tissues and organs can be induced into stem cells by regenerative activators when cells in our tissues and organs get necrosis, premature fibrotic ageing, degeneration, serious diseases and premature apoptosis. The stem cells will then regenerate new cells under the culture of regenerative nutrients to replenish healthy cells or replace the abnormal cells and restore the normal integrity of structure and function of tissues and organs. This is the mechanism of our HBRRS. And, what is the mechanism of ageing skin regenerative rejuvenation? That is to activate PRCs in skin and induce them to be stem cells to regenerate new cells and to replace senescent cells, in this way to maintain normal structure and function of skin organs.

Rejuvenation is in contrary to ageing. No ageing, no rejuvenation. The mechanism of regenerative restoration is mainly applicable to situations with skin-related diseases or defects. Today, we’re talking about the regenerative rejuvenation of ageing skin, of which the mechanism is clear and simple.

Speaking of this, you may think of some other methods of coping with ageing skin in our society. Then, what are their mechanisms? First, I would like you to ponder a question. Are there similarities between ours and theirs? The only answer is “No”. We should all be aware of that. Since they haven’t realized true regenerative rejuvenation of aged skin, their mechanisms are all false and are of no value. Their concepts are all wrong and have nothing to do with truth. You would be totally wrong if you accept any of their concepts.

Currently speaking, their methods can not achieve the regenerative rejuvenation at all. So, actually they have no mechanisms at all. If you are not clear about this issue, it means that you have not understood and grasped the HBRRS. Therefore, do not try to learn other so-called mechanisms since they have no scientific results, how can you expect they have their own mechanism, and how can you expect to learn something from them? Just as James Watson has negated the research of gene therapy, it would be of no value for you to still speculate the efficacy and mechanism of gene therapy. So, all of us should bear this in mind. If you make such a mistake, it means that you are totally unaware of what scientific truth is. Then, what is scientific truth? It is the result that has been accomplished. All hypotheses without confirmed results shouldn’t be regarded as truth. Once we follow such a principle, there would be no more fake concept. All those who devote into scientific research should be able to distinguish between “Scientific Truth” and “Scientific Exploration”. The scientific exploration is advocated. However, the exploration is done for obtaining results. Before obtaining results, all explorations may be useless and meaningless. In conclusion, exploration is not truth before gaining any results. Once there are results, the exploration can be deemed as truth, this is the principle of scientific research we must stick to.
Now, let’s go back to the topic of “Mechanism of Skin Regenerative Rejuvenation”. If you state it again, you should abide by the standard of truth. And, we should not follow the principle unique to politics that incorporates information of all factions, whether it is right or wrong. What we should do it to state the truth and criticize the hypothesis in the guise of truth. We should summarize and conclude the methods that help create truth. We must be clear in mind about this.

Let’s take our HBRRS as an example. For instance, if you are asked to “Summarize Research on Regeneration of Severed Fingers” and your review comprises in vitro regeneration and even some hypothesis without any results, your review would be unsuccessful. However, if you criticize these hypothesis and summarize the truth, your review is valuable. Once the experiment is finished and result is obtained, it turns out to be a truth. Otherwise, those which are not completed with results should not be deemed as truth. The concept must be made clear in order to further understand our mechanism.

In fact, today’s lecture may be unnecessary for our technicians since you have been working on skin regeneration for years. However, I find that you are still not clear in mind and fail to distinguish between truth and exploration, which results in failure of stating our scientific truth in a clear manner and instead, inaccurately presenting our truth as ambiguous concept. The accurate statement of truth and exploration requires strict definition. All in all, we should be careful and strict in terms of scientific research and tell the truth with facts. We should be aware of our advantages and shortcomings on the road of scientific progress.

Part Two
Section One: Regenerative Rejuvenation of Ageing Skin and the Mechanism

Today’s lecture on the mechanism of skin regenerative rejuvenation focuses on two parts. First, the main manifestations of ageing skin which is the critical basis for understanding mechanism; Second is how the regenerative rejuvenation of ageing skin is achieved such as procedures, methods and mechanism; Today, if you could understand the above two parts clearly, you can basically grasp the mechanism of regenerative rejuvenation of ageing skin.

Histology and Aging of Skin Organ

First of all, let’s go over the histology of skin organ that comprises epidermis and dermis. Basilar membrane serves as a boundary line between the two layers, and above is epidermis and below is dermis. In the epidermis, from the bottom up, there are basal cells layer and about 30 layers of cells which can be divided into four types: basal layer cells, stratum spinosum cells, granular layer cells and cuticular layer cells. Of course, among these cells, there might be small amount of melanin cells, Langerhans cells and Merkel cells. And dermis includes sweat gland, sebaceous gland, hair follicle, nerves and blood vessels, of which the openings of hair follicle and sweat gland reside on epidermis. But they are all appendages in dermis. Dermis mainly comprises three types of fibers: collagenous fibers, elastic fibers and reticular fibers. This is the basic structure of skin organ. Below the dermis, it is subcutaneous tissues.

Then, what are main manifestations of ageing skin?

I. Ageing of Epidermis

First, the ageing of epidermis starts from the basal cells which are actually stem cells of epidermis or the adult stem cells. They are left in the process of human development, accompanying our life all the time, from our birthday to the last day of our life. This layer of stem cells is not always in an active state. Its vitality will decrease while we are getting older, just like that of our internal organs. For example, the vitality of the basal cells in epidermis of an 80-year-old person is only 20% that of its young basal cells. And that of a 90-year-old person is only 10% of young cells. The decreased vitality of basal cells will result in decreased metabolic vitality of cells on stratum spinosum and granular layer and decreased metabolic speed of all layers of cells. Finally, excessive keratinization can be found, thus leading to ageing of epidermis. The manifestations include dim surface, coarse texture and enlarged pores and etc. Therefore, the skin of a newborn is delicate and smooth. No matter what their face look like, you will love them, since their metabolic speed of basal cells is fast and basal cells enjoy 100% vitality. And, the skin of the senior is coarse, loose and dim. No matter how they make up, they would fail to hide the fact, especially for European persons. Before 30, they look young and smooth, while after 30, their skin might be “horrible”, since the skin ageing process of Caucasians is even faster than that of the yellow. Therefore, we should be aware that the root cause of aging epidermis is the decreased vitality of basal cells, the slowed-down metabolism and decreased number of basal stem cells. Since this layer of cells is stem cells from which all epidermal cells originate. The stem cells in basal cell layer should be increased if you are going to regenerate and rejuvenate the epidermis layer. At the same time, the vitality of the basal cells should be enhanced to regenerate and rejuvenate this layer of cells, thus realizing rejuvenation of all layers of cells of epidermis. Otherwise, the epidermis layer will not be regenerated and rejuvenated.

Now, let’s take age pigment as an example. No matter how you treat age pigment by adopting artificial methods, e.g. laser, the age pigment will finally appear again. To understand the reason, we should first get to know the forming process of age pigments. The age pigment is one of the signs of skin ageing. The main reason is the decreased metabolic speed of basal cells, which is even similar to that of prickle cells. However, there is only one layer of basal cells, and there are 4 to 10 layers of cells that form the prickle cell layer. Such structure results in a continuous accumulation of melanin granules generated by melanocyte in basal cell layer between the basal cells layer and the prickle cells layer, thus gradually retaining pigments on the spot where melanin granules accumulate. And, such condition will further worsen the metabolism of basal cells and even lead to the stress hyperplasia of basal cells in the pigment remaining area. That is why age pigments usually appear locally and some of them are protruded hyperplasia. What we’ve said above is the forming process of age pigments. So, we can find that the root cause of it is the decreased vitality and function of basal cells. While adopting laser to get rid of age pigments, the color of stains might get lighter or the size might get smaller, but they would reappear soon, because the attribute of basal cells are still old and laser treatment does no good to the improvement of the functions and the metabolic speed. Therefore, the aforementioned process will occur again, and age pigments will reappear. So, removing age pigments with laser is only a physical technique, while improving functions of basal cells and rejuvenating basal cells are fundamental solution. Why we find no age pigments on the skin of teenagers and children? That is because physiological metabolism of their basal cells is in a young normal state. The formation of age pigments is resulted from a continuous process of epidermal ageing.

II. Ageing of Dermis
The second aspect of skin ageing is the ageing of dermis. First, let’s see the tissues in dermis, including collagen tissues, sweat glands, sebaceous glands, blood vessels, nerves and etc. Therefore, dermis ageing should be illustrated from these aspects.

Collagen tissues constitute the main part of dermis. And, the ageing of collagen tissues is actually the ageing of major tissues of skin. In order to understand the ageing of collagen tissue, it is necessary to learn its cellular component: progenitor of fibroblast, fibroblast and fibrocytes, distributing in dermis and subcutaneous tissues. Under normal conditions, fibroblast synthesizes collagen fibers, and the vitality of fibroblast directly determines the quality of the collagen fibers it synthesized, that is, if the collagen fibers are bundle-like, the collagen fibers are high in quality. If the fibroblasts are low in vitality, the collagen fibers it synthesized will be thin, fragile, loose and messy. On the contrary, if the fibroblast is high in vitality, the collagen fibers will be compact, strong, pliable, bundled and neatly aligned. Strong collagen fiber bundles can support the whole dermis layer and make the dermis plump and elastic.

Regarding to this, we have published contrasting pictures from the regenerative restoration research on rat models. In rats aged double of their lifespan in the regeneration group, collagen fibers in dermis are found to be strong and epidermal cells are neatly aligned, indicating the young state of the skin; while in rats aged the normal lifespan in the control group, the tissue slides showed cavities at all skin layers and scattered collagen fibers in the dermis that failed to support the dermis. The contrast in the research results suggested that collagen fibers in the aged dermis is loose and scattered, but is strong and bundle-like in the young dermis. These are real results from our experiment.

What are the causes of the different results? One reason lies in the different functions of young and aged fibroblasts. Another cause is that collagen and fatty acids are the major components of collagen filament synthesized by fibroblasts. For collagen fibers synthesized by normal fibroblasts, collagen accounts for 4%, fatty acid accounts for 96% and the quantity of filaments are normal. But metabolic features of aged fibroblasts are: declined synthesis of collagen with messy and scattered collagen filaments. At the same time, the synthesis of fatty acid is relatively declined as well, which fails to bundle the collagen fibers. Theses two aspects reflect the lower function of fibroblasts, because the gaps between collagen filaments are filled with fatty acids, and together they form collagen fiber bundles. Therefore, in order to regenerate and restore dermis, it is fundamental to make fibroblasts synthesize sufficient healthy collagen and make enough fatty acids. Rejuvenation can be really achieved only by this way. However, if we want to have sufficient fatty acid quickly, we need to provide the dermis with exogenous fatty acid to bundle the collagen fibers. This is the mechanism of how to rejuvenate skin after the first introduction of regenerative substances. Hence, in order to achieve real dermal regenerative rejuvenation, one problem is to improve the endogenous synthesis of collagen fibers, the other is to provide exogenous fatty acid required for the bundling of collagen fibers. Leaving these two problems unsolved, regenerative rejuvenation of dermis will remain a dream.

It is clear that dermis ageing results from the slowed-down fibroblastic metabolism that results in scattered collagen filaments, the declined synthesis and secretion of fatty acids that fails to bundle the collagen fibers, which in turn fails to support the dermis and consequently leaves a loose and saggy skin. Why do I stress on collagen fibers? Because it is the main part supporting the skin and directly affecting its elasticity and ductility. the above statement is the important mechanism of aging in terms of cellular metabolism. In light of cell survival, once skin organ is formed, fibroblast dies after 50 to 60 times of self renewal, for this reason, if we want to achieve regenerative rejuvenation, besides preserving the existing fibroblasts and maintaining their normal function, we have to bring the progenitor of fibroblast into full play, make fibroblast progenitors proliferate and differentiate into new fibroblasts to replace the aged dying fibroblasts, and this is another mechanism. Again, we are back to the core mechanism of regenerative rejuvenation, only through the activation of fibroblast progenitors will the dermis ageing problem be solved, the rejuvenation of dermis be really achieved. The metabolisms of sebaceous glands, hair follicle glands and epidermal basal cells share the same characteristics. However, the regenerative rejuvenation of nerves and blood vessels will be achieved through the systemic regenerative rejuvenation of the body, because it is hard to be realized through local introduction of regenerative substances. Since nerve endings and capillaries are the extension of nerves and big blood vessels, the regenerative rejuvenation, of skin nerves and blood vessels should be achieved with endogenous supply of regenerative substances. The regenerative rejuvenation, of skin nerves and blood vessels equals the regenerative rejuvenation of the whole body, for they are interlinked across the whole body.

In sum, the cause of skin ageing lies in the functional declining of fibroblasts in dermis and the basal stem cells in epidermis. In order to rejuvenate the skin, it is a must to realize the regeneration of dermis fibroblasts and the functional rejuvenation of epidermis basal stem cells, and it's definitely a process. We did a skin experiment with an American volunteer, with 3 introductions of regenerative substance in one week, the facial contour changed. How did this happen? As a matter of fact, the cells were not replaced yet, its mechanism is: the supply of exogenous regenerative substances bundled the collagen filaments, increased the vitality of epidermal cells, sebaceous gland, hair follicle gland, etc, and consequently rejuvenate the skin. In order to achieve complete and thorough regenerative rejuvenation, it is a must to regenerate and renew fibroblasts, enhance the function of basal stem cells, and there is a systemic factor, i.e., regenerative rejuvenation of subcutaneous blood vessels and nerves, which is closely related to the rejuvenation of the whole body. Skin regenerative rejuvenation, is therefore not an isolated task, it is one part of the whole body regenerative rejuvenation. All of our professional technicians should understand clearly the core mechanism of skin regenerative rejuvenation, and never confound it with the currently existing false concepts.

Section Two: Realization of the Technology of Regenerative Rejuvenation

How do we achieve the regenerative rejuvenation technology? It is partly mentioned in the above section, and will be summarized as below.

I. The Source of Regenerative Substances for Regenerative Rejuvenation

To realize the regenerative rejuvenation, the regenerative activators and nutrients should be introduced into tissues to activate the cells inside which then regenerate new cells to replace aged cells. Therefore, the core of regenerative rejuvenation is the regenerative substances.

How does the regenerative substance get into the skin? There are two ways: the first one is exogenous, including emulsifier, oxygen introduction, laser assisted introduction, etc; and the second is endogenous, i.e. provide the regenerative substances through blood circulation. As mentioned earlier, the animal experiment has proved that even without exogenous supply of regenerative substances, the skin still turned younger, which testified the effect of the endogenous supply of regenerative substances. For human skin, in order to make the rejuvenation faster, we draw support from exogenous methods to introduce regenerative substances. However, endogenous supply of regenerative substances is the primary means for regenerative rejuvenation of skin organ, the exogenous supply is adjuvant and should not be relied on solely. Take one of our clients for example, he started taking Elixir for regenerative rejuvenation at the age of 88. He is 96 years old now, but has rejuvenated his conditions back to the state of an 80-year-old already, which means 16 years younger. He never received exogenous supply of regenerative substances, but still turned younger. So, today I’d like to stress this concept: skin is the largest organ and its regenerative rejuvenation depends primarily on the endogenous supply of regenerative substances, and secondarily the exogenous supply. The same is true for gastrointestinal system. This is the relation between systemic and local changes, and we must understand it.

In terms of skin itself, it is one part of the body organs. Without the regeneration of all body organs, it is impossible to realize the significant overall regeneration of skin alone. Even if there is younger appearance occurred, it won’t last long. It can be manifested by the experiment of the American client, he received three-time exogenous supply in a week and he looked younger immediately, but did not obtain rejuvenation yet. This is the scientific truth. Many clients did not receive exogenous supply, but they all turned younger. Only that those who received exogenous supply rejuvenated in a faster and more obvious way. In light of the effects of the endogenous supply and exogenous supply, you should distinguish the primary from the secondary.

II. Technologies

Currently, it is quite clear that endogenous supply can be delivered through oral administration; but we have been exploring the best ways to provide the exogenous supply of regenerative substances. Here, I will talk about the technologies we are using now, including: first, nanoemulsification which helps realize easier absorption compared with regular emulsion; second, oxygen-assisted introduction, it is a confirmed, mature and effective technology; third, the fractional laser assisted introduction that is undergoing experiment; fourth, small area local injection of nanometer regenerative substances that will be in experiment.

The purpose of the said methods is to accelerate the process of local regenerative rejuvenation. But basically speaking, no matter which method is used, it is impossible to radically solve the ageing problem of dermis and rejuvenate it if fibroblast replacement is not achieved. The epidermal cell requires no replacement, because the epidermal basal cells themselves are stem cells which only need to increase vitality. Young people’s skin is fine, smooth, moist and tender, because it has not reached the time of dermal collapse and the vitality of epidermal basal cells is not affected yet. Therefore, there is no need to use oxygen-assisted introduction or laser-assisted introduction for them, only external application of our cream can maintain the skin in a young state since the cream can maintain and increase the functional vitality of epidermal basal cells. But for aged dermis, cream alone exerts hardly any effect, that is to say, if we only want to improve the epidermis, topical product alone is enough. In the near future, we will launch a large quantity of products to the public, if you want to rejuvenate your epidermis, use our products because it can increase the vitality of the epidermal basal adult stem cells which can achieved by our products only, not any other products.

III. Realization of the Technology of Regenerative Rejuvenation

Next, I’d like to talk about the key procedures of how the regenerative substance works in the skin organ through these technological means.

1. Realizing Epidermal Regenerative Rejuvenation
As aforementioned, we have talked about the changes of basal cells in the aged epidermis. Epidermal basal cells are mainly comprised of adult stem cells and their vitality is inversely proportional to age. The vitality of epidermal stem cell in a 90-year old remains only 10%, so does that of the cell in dermis. This is a law we summarized; this is also true for other organs in the human body, as manifested by other organ’s fibrosis like pulmonary fibrosis and liver fibrosis. So, the first problem we are going to solve is epidermal basal cells, because the exogenous supply acts through natural absorption, the substances can permeate through the skin via the interstitial space and into the epidermal basal cells. Endogenous supply enters through skin capillary that extends to the semi-permeable basilar membrane, while regenerative substances in the blood vessels can also permeate through this membrane to nourish epidermal cells, including basal cells. For this reason, if the client is young with non-aged basal cells, exogenous supply can be used as the only supply to prevent decline in the vitality and function of basal cells; it the client is aged, both endogenous and exogenous supply of regenerative substances should be provided, because the regeneration of epidermis needs both and they can not be separated in this condition. So, in order to understand the mechanism, it can not be viewed from a single perspective. Without the blood circulation, the endogenous supply of nutrition cannot be delivered, and it will be difficult to maintain the skin basal cells in a young state. Though it does not require activation since it is stem cell itself, but to keep or rejuvenate the young state of epidermis, it is necessary to have endogenous supply of regenerative substances.

2. Realizing Dermal Regenerative Rejuvenation

After introduction, the fatty acid compounds included in the regenerative substance turn the scattered collagen fiber into bundle-like, restoring immediately the elasticity and plumpness of the dermis.

Main structure of dermal tissue is collagen fiber. As we have mentioned before, the regenerative rejuvenation of dermal tissue mainly depends on the supply of endogenous regenerative substance. This is not an imagination but has been proved via experiment result in which rats are still young at age of double lifespan. We are now supplying regenerative substance via exogenous approach to regenerate and rejuvenate dermal tissue. Dermis is connective tissues with space between tissues thus regenerative substance can reach the dermis once it penetrates through basement membrane. We supply regenerative substance via emulsification but only small amount of substance can penetrate basement membrane. It is hard for exogenous product used on the surface of skin to penetrate basement membrane unless it is toxic substance with strong penetration. However, our regenerative substance is nutritional substance and comprises natural compounds with large molecular weight. But it has been proved in the practice that regenerative substance does reach the dermis. For example, the American guest we mentioned above showed signs of rejuvenation within 7 days which indicates that fatty acid has reached the dermis. Such fatty acid is the mixture of regenerative substance with the fatty acid being bound with regenerative activators. The mixture of regenerative substance will reach the dermis along with fatty acid. The fatty acid carrying regenerative substance plays two roles after reaching the dermis: one is to nourish the regenerative cells, and the other is to turn scattered fibers into bundle-like. However, the bonding effect of fatty acid will decrease along with the consumption of nutritional substance. Thus, bundle-like collagen fiber will turn into scattered several days after each introduction of the regenerative substance unless real regenerative rejuvenation is realized. For example, facial effects of Mrs. GAI Xiao-xia highly proved the point above. She went to USA three months ago and discontinued the introduction of regenerative substance, so the skin turned back to the aged status. But her skin turns young after re-starting and enhancing regenerative substance introduction. Of course, we have to mention that even though her skin turned back to the aged status after long time overseas stay without exogenous regenerative substance introduction, she still looks much younger than her conditions before applying the regenerative restoration program since cell restoration is a gradual process. Fatty acid substance accounts for a great part in the regenerative substance, of which fatty acid can be metabolized in dermis and be used by various cells in this layer. Skin will become dark if the fatty acid that can not be metabolized in cells enters into dermis.

Without doubt, only small amount of regenerative substance can be imported into skin via oxygen under the condition of no skin injuries. Because basement membrane is a semi-permeable membrane, oxygen can penetrate this membrane. Regenerative substance will be carried into dermis by oxygen. Another route for regenerative substance entering into skin tissues is oral administration. It will enter into blood circulation and finally reach to dermis to nourish fibroblast (progenitor) in dermis. The amount of regenerative substance obtained from blood circulation is even less than those absorbed via exogenous introduction. But the regenerative substances from blood circulation can be used sufficiently by the cells while those brought by oxygen may not be used sufficiently. The reason for this is regenerative substance brought by blood circulation can carry various biological activity information of the body through the process of digestion and absorption in the body. But regenerative substance brought by oxygen is a kind of physical supply which lacks biological activity. Therefore, all the exogenous approaches to supplying regenerative substance such as emulsification, oxygen and laser introduction are supplements of endogenous supply. The one that can take real effects on regenerative rejuvenation is endogenous regenerative substance.

Now we will reveal the mechanism of laser-assisted introduction of regenerative substance. We should not take laser-assisted introduction as one of the techniques of regenerative rejuvenation. From the day it was invented till now, fractional laser has no real effects of rejuvenation, except that Dr. TAN Jun has achieved modest effective application. The mechanism of laser is not well-established and one of the so-called theoretical bases of fractional laser is to promote cell apoptosis. Then what is apoptosis? First, we have to clarify the concept of apoptosis and apoptosis refers to programmed cell death.

Here, I would like to supply more knowledge about apoptosis. Cell apoptotic necrosis and cell necrosis caused by damage are two different concepts. What is apoptosis? Apoptosis refers to the programmed stop of cellular metabolism, which means cell is still intact when it is dead just as it was previously born with intact cell membrane and no contents leakage. They just wait for phagocytosis by the phagocytes of immune system. This is called apoptosis. What is necrosis? Necrosis means cellular membrane is damaged with contents coming out. Large amount of content release can cause systemic reactions. Meanwhile, the damaged cell is incomplete. That is called necrosis. Therefore, apoptosis does not cause systemic reaction but only immune system reaction. But, necrosis will result in systemic damaging effects and we must be quite clear about these two concepts. So, what is the mechanism of fractional laser? The mechanism of fractional laser is to make skin tissues in a targeted area carbonized in a very short time via super high heat and thus cells are gone. So this is not cell apoptosis but cell disappearance (defect or lost). Others may say laser can lead to cell apoptosis around the carbonized area. But actually the so called apoptosis is necrosis, and necrosis can result in systemic damaging effects and this has nothing to do with rejuvenation.

So what is the real mechanism of using fraction laser to make skin look younger? Through laser heat induced carbonization, factional laser turns integrate skin tissues into cellular status and the cavities are the missing skin tissues which reduce the size of skin. Skin looks younger and tight than before due to scar contraction on the traumatic area, but it will turn loose several days later. The degree of shrinkage of human skin can reach 20, therefore skin can maintain young state only when the collagen fibers maintain normal elasticity. Facelift and fractional laser have the same mechanism except that facelift may have quicker effects. However, skin will turn loose soon again. The true mechanism of fractional laser realizing firm and tight skin is to reduce skin size, which is very simple. What we should note is that no scar will be left after laser operation if it combines with post-operational application of MEBO. Otherwise, scars may be left. If MEBO is not used after laser operation, whether scar will form or not depends on the wound size and self-healing ability of the human body. Then, how strong is the self-healing ability of the human body? As long as the wound is within 5cm in diameter it can heal spontaneously. That is why small mole can be removed by laser but large mole can’t--scar will form after large mole removal. For example a mole on the skin is removed via laser, the local tissue will shrink. Any trauma is an irritation to skin tissue, e.g. fractional laser causes traumatic irritation to collagen fiber. But irritations brought by fractional laser and burn are different. For skin heat injury will result in three damage zones. but for fractional laser, there is only one zone – the necrotic zone. After removing mole via laser, size of skin tissue in the affected area decreased. This has been indicated in the instructions of laser which says, “The decreasing size of skin tissue depends on the density of fractional hole”. What is the reaction of skin after laser operation? Traumatic irritation brought by laser triggers fibrocytes proliferation to fill the defects of affected area. Meanwhile, elasticity of fibrocytes also decreased, thus the affected area will contract and skin tissue size will decrease.

This is the true explanation of laser cosmetology and all the other theories are just false since we have in-depth understanding of the mechanism and other theories are just like making up stories. Some of the doctors use MEBO after laser cosmetic procedures and they may have good therapeutic effects, but they misunderstand the theory of regenerative restoration. Because laser does not make normal cell regenerate, instead, they remove tissues via heat and leave the spot an inflammatory reaction which is nothing but a stress reaction after traumatic irritation.

Then why do we still use laser? We use it to make holes on the skin with laser and generally the holes are not very deep (except for scar management). They are only deep enough to penetrate basement membrane. We make artificial tunnels via fractional laser for regenerative substance to enter into skin. Regenerative substance can enter into dermis through these holes on basement membrane and diffuse to form a regenerative nutritional environment after reaching the dermis since dermal tissue is loose. The amount of regenerative substance entering into dermis in this way is much more than those brought by oxygen. However, these holes will finally close and after repeated experiments we find that basement membrane tunnel will close 2 to 3 days after laser operation while epidermal tunnel will close after 7 days. We use oxygen-assisted introduction 7 days after laser operation. Two to three days after laser operation, amount of regenerative substance reaching the dermis is much more than that introduced through ordinary ways. Moreover, we also find another phenomenon via a comparative experiment. Affected area will be red after leaser operation if regenerative substance is not imported. On the contrary, the affected area will not be red after laser operation if regenerative substance is imported. The redness on the affected area is inflammatory reaction which is the stress reaction after trauma. Regenerative substance has strong anti-inflammation effects which is not found in this experiment but is just proved via the research of burn management. We started our burn research by using burned rats model and we found that rats without applying regenerative substance had red wound due to the blood stasis of deep second degree burns. On the contrary, the wounds of other rats applied regenerative substance were normal like those who have never been burned. The necrotic tissues appeared on the wounds several days after burn. But wound with regenerative substance has thinner necrotic tissue while wound without regenerative substance has thick necrotic tissue which would gradually form eschar and even progress to third degree burn. Wounds with regenerative substance show no redness and after the liquefaction and removal of necrotic tissue, the wounds will gradually regenerate new skin which indicates the anti-inflammatory effect of regenerative substance is strong. It will be clearer if we examine the wounds under microscope. We can see blood circulation in a scald wound after being given regenerative substance, though part of the vessels necrotized. There are still some vessels maintaining circulation, thus reducing inflammation. However, blood stasis gradually and finally forms embolism in the scald wound without regenerative substance and aggravates inflammatory reaction. Moreover, we have also confirmed the anti-inflammatory effects of regenerative substance through control experiments.

Speaking of the laser introduction, the golden time for regenerative substance importing via laser holes is within three days, since after three days theses holes on basement membrane will close and the affected skin feels coarse and seems that there are a lot of small protuberances, which is resulted from the closing of basement membrane. However, the epidemic carbonization still exists which can be discharged outside layer by layer through epidemic cell metabolism. Thus, the area performed laser operation feels pricky, just like many small pillars protruding from basement cells and each hole is like a pillar. We use laser operation to increase and enhance quickly the amount and efficiency of exogenous regenerative substance import. Meanwhile, laser can cause micro-invasive injuries to dermis. Firstly, it can accelerate the activation of progenitors of fibroblast to regenerate new fibroblast replacing the aged one. But we must keep in mind that fibroblast progenitor activation must be realized with following introduction of regenerative substance to make sure that it is physiological activation. Otherwise, it is pathological activation. On the other hand, fibroblast can be simply activated via trauma. If no regenerative substance is given, a large number of fibrocytes will proliferate after injury with disorganized order, fibrosis and finally scar formation. If we give regenerative substance via laser-assisted introduction, then collagen fiber produced by fibroblast will be physiological and arranged orderly, and pathological fibers will be replaced by physiological fibers gradually. This is the result we got from our scar experiment in which we drilled holes on scar tissue via laser to introduce regenerative substance, and then neatly arranged collagen fibers were produced by fibroblasts.

Up until now, we are clear that laser operation used in our research is only to make a pathway on the skin surface to deliver exogenous regenerative substance into the dermis rapidly. But, endogenous regenerative substance supply must not be given up and ignored. Exogenous supplement of regenerative substance is essential channel for skin regenerative rejuvenation. But another vital channel is also necessary which gives regenerative substance endogenously. It has been proved by animal and human experiments that skin regenerative rejuvenation can also be realized only with oral intake of regenerative substance without exogenous supplement. However, it will take more time and the results are not so satisfied. Now we have manufactured special oral solution of regenerative substance – MEBO Essence for Skin Regeneration which can put skin in a three-dimensional environment surrounded by regenerative substance to realize the regenerative rejuvenation of aged skin organ.

Section Three: Mechanism of Regenerative Rejuvenation of Aging Skin

Summing up the above, it is vital to clarify the principle of laser-assisted introduction of regenerative substances and the mechanism of skin-organ regenerative rejuvenation.

Firstly, laser operation is used to establish channels to carry regenerative substance into skin tissues which, meanwhile, causes the traumatic defects to skin. Indeed, the so-called cosmetic effects of laser are misleading in that after laser cosmetic surgery, slow fibrosis and pycnosis of fibrotic tissues will take place in involved site, which in turn can tighten up the surrounding skin, giving the appearance of tightness and youth. But in fact, it is the result of tissue fibrosis and the normal physiological structure of skin has disappeared. We call these fibrotic tissues as micro scars which could be absorbed quickly within a period as short as about one month. Sometimes, the period may be 3months as the absorption is not good. And for larger scars, the period of restoration may be 2 years. So the seeming tightness of skin is only false appearance since 1-3 months later, the tightened skin would return to its original state before laser surgery, thus it is invalid surgical operation. Now, though we are still at the testing stage of laser-assisted introduction of regenerative substance, we have obtained some successful results in some cases. The next step we are to conduct experiments on applying laser operation of different energy levels. In theory, more regenerative substance would be introduced into thedermis as there are more holes drilled by laser. However, our experiments should make sure that no traumatic micro-scar is formed, otherwise, the experiments are meaningless. The reason why we use laser, is not for the cosmetic effect of laser, but to quicken the transportation of regenerative substance into the dermis though its chronergy lasts only 3 days.

Secondly, oxygen-assisted introduction of regenerative substance is still major regular operation, which can not only help the import of regenerative substance but also play the function of physical massage on topical body organs. The mechanism of physical massage is to generate one type of shock wave on the surface skin through the reaction of two atmospheric pressure and the shock wave could vitalize subcutaneous tissues and muscular tissues. Take body exercise for example, our muscles would get atrophied if not exercised, while for those who exercise frequently, the muscle is highly active in terms of function. Thus, the oxygen introduction can give the muscle in the affected site a kind of physical activation inside and out.

Thirdly, we have received very good feedbacks on the emulsification technique of skin regenerative restoration being applied among our club members and guests. The next step is to perform nanoemulsification technique turning the regenerative substances into tiny particulates of mega level to facilitate the absorption and emulsified penetration into the dermis layer. Now we are at the experimental phase. The technical procedures of nanoemulsification of regenerative substances has the same goal as laser introduction, which is to transport the exogenous regenerative substances inside the skin tissues as much as possible. Only via the approach to transporting the regenerative substances in vivo creating a regenerative environment for regenerative life can we realize the regenerative rejuvenation of all skin tissues and organs. The other components consisted in the skin cream products only play the role of protecting skin and the truly effective component is the contained regenerative substance.

All the above is the core content of today’s lecture.

Part Three

Summary of the Lecture

To learn more about MEBO technique and master its mechanism and theory, people should be fully aware that currently no technique in the world could really rejuvenate the human body. All the propagandas of so-called rejuvenations are purely market hype of cosmetic companies, and only MEBO regenerative substance can realize regenerative rejuvenation. Exogenous introduction of regenerative substance is to activate the potential regenerative cells in local skin, and with the advantage of fibroblast progenitor innately existing in the dermis, the fibroblast progenitors are actually the potential regenerative cells which once are activated can produce a large number of fibroblasts, especially in the case of trauma (trauma can activate a lot of fibroblast progenitors). However, it is only a sort of pathological activation in comparison to our activation by using regenerative substance imported into skin through natural emulsification, micro-invasion and oxygen-assisted introduction. When a cell is died, a new cell would replace the dead one in situ. The regeneration of cells and the enhancement of cell vitality would make the produced fibers bundle-like. In regard to epidermal basal cells, they are originally adult stem cells, thus they are free of activation and what they need is to enhance their functions as stem cells. As a result, the proliferated and differentiated new cells will appear young with normal functions, for which we have obtained cytological data as scientific basis.

The major purpose of today’s lecture is to get everybody understand and master the mechanism of rejuvenation of aged skins. Actually, cells existing in different parts of tissues and organs would experience the same transformation of non-functional cells into fibrocytes. For example the aged hepatic cells, they become fibrocytes as they lost their functions. The increasing of fibrocytes in the body is the representation of body ageing. Speaking of skin, it is the ageing of skin. Our target is to use the fibroblasts to replace the fibrotic cells in situ. If the function and number of fibroblasts are normal, the dermal layer will be full and elastic, which is the sign of skin regenerative rejuvenation. In some areas like tendon, only fibrocytes exist, playing the roles of connecting and supporting. When people get old, tendon rupture would occur easily, losing the supporting function. Such fibrocytes are different from the previously mentioned senescent fibrocytes, once they become real fibrotic cells, they will have no any function like weeds. We should bear in mind this concrete concept.

Therefore, the essence of skin organ regenerative rejuvenation is the replacement of fibrocytes which can only be realized through the introduction of regenerative activators and nutrients. Currently, the approaches we are applying include the exogenous regenerative substance supply by the natural emulsification, oxygen-assisted importing and laser-assisted, and endogenous supply by oral administration. The endogenous way is primary while the exogenous is auxiliary, playing the combined effects. For the regenerative rejuvenation of the epidermis, the focus is to strengthen the vitality of basal stem cells, which is a prerequisite, while for dermis it is to activate the fibroblast progenitors to generate new fibroblasts in replacement of the nonfunctional fibrocytes and meanwhile to enhance the function-degenerated fibroblasts so as to produce young and healthy collagen fibers. Moreover, via the introduction of these nutrients, the scattered collagen fibrils could be turned into bundle-like which could keep the skin tightened and elastic. For the regenerative rejuvenation of blood vessels and nerves, it can be realized after the holistic regenerative rejuvenation of the human body because they are the continuation of the body; for the regenerative rejuvenations of skin appendixes like sebaceous gland, hair follicle and swear gland and etc. are the same as that of epidermis since they also have adult stem cells and they are developed from the epithelial tissues, hence their regenerative rejuvenations can be realized only by enhancing the functions of these adult stem cells. In addition, oxygen-assisted introduction can also play the role of shock wave to enhance skin vitality and promote the passive activity of skin and body surface organs, just the same effect as the proverb indicates, “Smiling often can make people much younger.”

All the above are the technique mechanisms of regenerative rejuvenation of aged skins, all of us should ponder over them from the inside with the standing on top of the world. All the achievements are derived from HBRRS which has brought human beings into the world of regenerative life, the greatest contribution of the science to human beings, and in the future it will bring about much more comprehensive changes and benefits to the mankind in many ways!

Edited by Life300y Club of Beijing Rong-xiang Institute of Regenerative Medicine

To be published in the Issue 4 of The Chinese Journal of Burns Wounds & Surface Ulcers

Human Steps into the World of Regenerative Life

XU Rong-xiang

Editor’s Note

As the self negation of Watson on gene therapy and the rise of Human Body Regenerative Restoration Science (HBRRS), great changes have taken place in the pattern of life science around the world. Throughout the history, the development of science and technology inevitably influences and impacts the revolution of economy, politics, related industry and agriculture, and life energy industry. In such a situation, Professor XU Rong-xiang, the founder of HBRRS, recently made an academic report (on April 13, 2025) under the title of “Historical Development and Prospect of Life Science” to prospectively analyze the development history of natural science, life science and medicine in a penetrating way and finally concluded the gene therapy theory coming to its end and HBRRS coming in and enjoying broad prospects, which is the reality of today's most cutting-edge science. The report made by Professor XU impressed the attendees a lot by its profound meaning, strategic views and humorous and easy-to-understand language. In order to benefit more scholars and professionals, we specially organized, edited and published it in the academic journal according to the report video to share with readers.

Good morning, Dear all:

The reason why I make the report today mainly is that the status of HBRRS system in the world, i.e. the global big family, has been changing tremendously, and the change relates to the changes of life, economics, society and even politics in the future of all human beings rather than only involves to a scientific achievement simply or the economic development of a company. We are the sponsor of the human tremendous change that will happen in the future, and thus we should firstly grasp and understand the background and future development of the human life science which will revolutionize the world.

What I say today actually is a science popularization education, a comprehensive knowledge education covering the history, present and future of the science. You everyone should know what the science is and everybody should have the power of understanding.

As you all know, on the planet we live, the development of every new science will inevitably bring about great changes to human life. So what are the changes following the next development? As I have already said before, humans will enter a new era of HBRRS system. That is to say, human will enter the era of human regenerative life, which is the theme of today’s report.

Today what I am going to talk are the same to everyone present and no matter whether you are professional or not, you all can understand it. After all what we are doing is a science popularization education of human regenerative life world. We have the obligation to understand it firstly since we are all in for human services. We are exploring in the road of scientific research and we are producing our products, which are visible and concrete. However, what our HBRRS can bring to human beings? I believe after you’ve figured out the question, fundamental changes will happen in the development of your future work, career and even your family life.

Today, under the title of the new era of human regenerative life, I make the science popularization education on what changes the future life science will bring about to human life. Now, let’s talk it from the following three stages.

I. Life Science in the Human Ancient Age: Savage Enlightenment

Summary

The fifth century BC is the time when the ancient human gradually evolved into the development era of life science from the state of living the life of a savage. However, at that time the main source of food is still the hunted animals and plants and also at that time the laws of food and life were concluded, which is the beginning of life science taking place tremendous changes. Even though at the time when the human diseases were caused by Nature and in turn Nature cured them, life science was still very active. In China, a cohort of medical scientists led by Bianque pioneeringly made use of the natural material to treat diseases and established diagnostics, while in the western, the development stepped into an era of scientific medicine from the ancient age of science. Gregor Mendel discovered the chromosomes and in 1907 the chromosomes was molecularized into deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), which was the earliest time when human genetic material was determined. Unfortunately, until now, the idea of human beings treating diseases by making use of genetic material ended in nothing.

So what’s like the development of human life science in ancient time? The so-called ancient time of human life science refers to the period when the ancient Greek Hippokrates lived, that is, starting from the 5th century BC.

The time before the 5th century BC is the development era of human ancient life science, which was developed from the well-known ancient human life. So what’s like the ancient people life? Human beings maintain their lives by catching fishes and rabbits and eating animal meat, and then they found some plants and tried to eat to make sure they are edible and gradually they found more edible food from the beginning dozens of types to later hundreds of ones; moreover, they found that after they ate plant food they can eat less animal meat, which is the origin of laws of food and life. With the evolution of people's thoughts, they doubted that some sick people died while others lived on well, but they had no idea what the reasons were. However, that was just the time when the theories about heaven god and earth god came into being, which was the period of ancient witchcraft. As for how could this be, it is quite simple to understand: they were innocent; and so medicine in ancient time was mainly the witchcraft. But why was that? This is a probability problem. For example, there are ten people with the same disease, but they can't all die consequently. Once the witchcraft was performed and by chance someone survived, it was reported the witchcraft saved him without reporting anything about the dead cases. This kind of witchcraft lasted for nearly ten thousands of years.

People later produced a sense of natural science when they found that they can still survive after eating some plants as they were sick, which marks that human stepped into the development period of human life science in the posterior ancient time (i.e. the period during which the witchcraft fought against the Nature), and the establishments of China’s earliest traditional Chinese medicine and the western medicine in the western world are the outcome of the fight. Originally, the ancient people used diamond to treat diseases. They thought mirroring the disease on the diamond and the disease can be cured, which is a progress from a stage of treating diseases with a virtual witchcraft to a stage of material therapy. But the disease being cured is by chance and attributed to a coincidence. Later, the natural organic material was found to be effective to treat diseases and it took the place of diamonds, which is the science of the ancient world.

The 5th century BC is a period when the life science took place great changes, of which the essence was that the human diseases resulting from Nature can be cured by Nature. At this time, life science was very active and vibrant. In China, a cohort of medical scientists led by Bianque pioneeringly used natural material to treat disease and later based on the treatment course, they established diagnostics. This was the situation in China, while in the west the medical development was much faster. Thus, human entered into an era of scientific medicine from the ancient stage of science.

The era of scientific medicine includes many parts including the use of natural substances in therapeutics and the means used in diagnostics. Human body was classified and categorized in accordance with the functions of different body parts. The era was represented by Hippocrates who was the father of modern life science and modern life science or modern medicine begun from that time. But the blueprint of life science planned out in that time has yet not to be completed. That is to say, from the ancient time to the present modern era of medicine for more than 2500 years, human studies of medicine has been confined to that category until to the birth of HBRRS.

The development history of human life science is actually very simple. That is, human, under the medical system and categories developed by Hippocrates, gradually invented anatomy and then discovered the bacteria, and further studied to attack bacteria and consequently antibiotics were invented. Human body as a whole was divided into several systems including fluid system and etc. and blood system in fact was first put forward by Hippocrates. Henceforth, a number of scientists focus on different systems emerged.

With the inventions of telescope and microscope, human has the ability to know the outline of the body internal organs and also cells were observed. And thus cytobiology was born. From cytology itself to now, the medical science hasn’t yet jumped out of the scope defined by Hippocrates. So what has been developing the science in those years? From the perspective of therapeutics, in addition to the more modern and more accurate technologies for diagnosis, the science materially experienced the use of natural substance treating diseases 2500 years ago, abstract substance treating diseases just like refining gold from stones in the Renaissance to form compounds, and consequently the appearance of chemistry and biochemistry. Since then human entered into the chemical era of treating diseases. However, both in the chemical era and the previous ancient times, the treatments all targeted at the diseases themselves and the situation lasts until now.

From the beginning of modern medicine 2500 years ago to now, there is no real breakthrough in treating the organ diseases. For example, to remove an acute gastroenteritis, can modern medicine cure it? Although modern medicine has developed so strongly, there is still no any technology curing the organ diseases of human body. Even the recovered disease is not cures by the medicine itself and some diseases can heal by themselves without any medical management, for instance a cold which can heal by the immunity of your own body, and so does the flu, and there is no data which can prove that modern medicine can cure it. Nowadays, avian flu is popular, which is a kind of flu virus carried by poultry and is regarded as a new variant of avian viruses. No one knows how many variants human beings have contacted with the viruses!

The methods of human against these diseases are more advanced than the original in that originally it is the body's own natural immunity which now can be replaced by artificial immunity to prevent diseases. But what’s the evaluation of the artificial immunity? Someone says it is effective, but it may be harmful in the long run. Temporarily, it can indeed save some people but the evaluation of it is just the same as that of antibiotics. Human found bacteria can cause diseases and tried hard to find a way to kill bacteria (which is the reason why antibiotics coming into birth). However, now someone once evaluated that the greatest flaw of human is the invention of antibiotics in that though antibiotics can temporarily save people it finally kill people. To this, we don't want to judge since human has to figure out ways of survival among struggles. The innate immunity of human body is different from the artificial immunity and the immune genetic material discovered by Gregor Mendel, which is obtained from the practice of mankind history. China has a long history of medical record but from the ancient times to the modern time when the whole medicine develops to today’s stage, though many methods appeared, there is no any real method of treating the human organ diseases radically.

In the lentils hybridization studies, Mendel discovered a substance in biological cells and called it chromosomes, so what is the chromosome? It decides the life of an organism. However, the published article of Mendel was not be found until 40 years later when some professors of Brockport, New York were studying the relations between organism and the genetic material, they obtained the same result as that of Mendel. At that time, scientists were more sincere and didn’t pass off or plagiarize Mendel’ discovery. When they found Mendel’s paper in the storage of the library that published in the school journal, they compared it with theirs and found that they were totally the same. After published the scientific achievements, it was proved that the father of genetics was Mendel rather than the professors of Brockport. Since 1907, people begun to chemicalize or molecularize the chromosome and in this way ribonucleic acid (RNA) and deoxyribonucleic acid (DNA) came into being.

The year of 1907, please remember the time which is the earliest time when human genetic material was determined. Since then people would like to further explore the mysteries of human life from the chemical perspective; Secondly, after finishing the chemical-perspective study, they wanted to cure diseases by genetic materials. Narly half a century has passed, however, the dream of human exploring genetic material to treat the disease comes to an end, and no achievement has been obtained.

Part 2 The development and stagnation of modern medical science---doom of gene therapy

Key note:

Since the discovery of three dimensional structure of genetic material by modern medical scientists as well as the development of electron microscopic technology, eventually three scientists, i.e. Watson, Crick and Wilkins jointly found the dimensional structure of genetic materials and therefore were honored as “the father of modern genetics”. They are considered the greatest life scientists in 20^th century; genetic molecular biology is taken as the greatest science. From 1953 till now, there have been a total of 47 Nobel Prize awards granted in terms of genetic molecular biology. Nobel Prize has been a mixed success flicking with philistinism in science community. The inane news-making speculation of scientific concepts like transient embryonic stem cells and iPSCs are lies. Recently, after half a century, Watson “the father of modern genetics” revealed the truth. The self negation of Watson in genetic therapy research indicates the age of modern medical science, the scientific system established by Hippocrates has not terminated yet; human organ diseases are remaining unsolved today. As early as 2002, Prof. Rongxiang Xu, the Chinese life scientist had pointed out the highly agreed human genome spectrum was actually severely flawed in scientific aspect.

In 1953, European and American scientists discovered the three-dimensional structure of genetic material. With the development of modern electron microscopic technology, people can take more and more delicate observations, and eventually three scientists including Watson and Crick jointly found the dimensional structure of genetic materials. They are called as the father of modern genetics because genetic material is the expression close to life properties and information of humans. They should actually not be called as the father of modern genetics strictly since it was not them who first found the structure, but they outlines the possibilities for an understanding in its finest details of the molecular configuration. Now two of those three scientists have died and Watson is the only one still alive. Watson, who has been attracting much public attention on the internet, is the greatest life scientist in the twentieth century. The greatest science is genetic molecular biology.

The initial stage of cell life genetic study began from genetic chromosome studies to chemical identification of genetic material in 1907. The study diverged into two trends afterwards: one is to study continuously on human cell genetic material, i.e. chemical property of RNA; the other is to guarantee human health by changing such chemical property, strictly speaking to treat diseases. But there has been no progress after half a century.

Since the three-dimensional DNA structure is introduced into life, Watson mentioned in his statement that here came another dream when people knew the real structure and life activity of human genetic material. Is it possible to cure diseases by changing its structure? He began to decode and analyzed the double helix structure of DNA gradually. It was just like getting to know a building. You have to destruct it into powders and investigate what the concrete is made of before you can get any secrets out of it. That was what Watson thought then. He attempted to find the key to human diseases by this way. Therefore, the discovery and decoding of double helix structure of DNA by Watson in 1953 is considered as a turning point in life science. What is this new turning point about? It’s cutting-edge study on life science. What is the cutting-edge study about? It is to resolve the uncovered problems left by conventional medicine. The motive and goal are the same: to cure organ diseases intractable by modern medicine. Their slogan is to cure medically incurable diseases. In fact, human organ diseases is the major problem, which is quite clear based on our study of the four paths of cell in tissues and organs going to death: fibrosis, mutation, disease and apoptosis. And that should be seen as another boundary, after which the modern medicine should be divided from 1953 if it can cure human organ diseases. That means conventional modern medicine began and medical science was over. However, the study on genetic molecular biology has no progress till now as Watson himself confessed on March 21, 2025 that sequencing genes isn't proving to be particularly useful in fighting such diseases as cancer and that much of the research being done on the subject is irrelevant. It is just more respectable for a man like him to realize that than his fame as a Nobel Prize winner. As the matter of fact, it is undoubtedly that any method of changing genes would generate a new species since gene is the locating marker of human life property based on the analysis of basic scientific principle. Like virus, when the flu virus changes, it will change into a new species. And using the new species to fight against the former one will cause a new circulation of a microorganism affected disease. This unreliable route is the parochial part of the ideology of western medicine of the time.

I never feel too confident to say it is not Rongxiang Xu who is great, but the scientific principle and the world outlook we use to investigate every scientific event is right.

From 2001 to 2002, I have been releasing my claims when the genome trend prevailed wildly. Some crazy story even reported people could foretell their potential risk of car accident by human genome sequencing. It was so ridiculous when you think about it: a car accident can never be caused by the driver but others; otherwise, the driver will be a psycho. It is such a shame for humans to still hold enthusiasm in their deviant “civilization” like this. That is when I had to make a voice (cited from the report by WENWEIPO: August 17^th of 2002, Great Defects in Human Genome [Peng Lei, reports from Beijing News Center on 16^th] Prof. Xu Rongxiang, life scientist from China, pointed out today that great defects remain in the human genome scientifically. He said that human genome is very important with regard to the research of genetics and the genome is authentic. However, the genome declared by them features washing off the genes from DNA structure using chemical elements, which makes nucleobases generate moving curve lines under the influence of capacitance technology, serving as a sequencing means of genetic materials by means of capacitance technology. But, it is not an authentic sequence pattern in human body. Mr. Xu Rongxiang simplified obscure scientific terms into a vivid analogy: It is just like apples on a tree. Each apple has its own position on the tree. However, when people take them off and arrange them on the ground, they couldn’t match the exact branch from which every single apple comes from. Mr. Xu said, “Great defects in human genome feature the totally unauthentic structure result.”

Gene sequencing is to wash off genes with an enzyme and then arrange them in orders. It is the same as the fingerprint spectrum, each wavelength representing one material. The base-pair material of RNA is various among individuals and therefore gene sequencing is regarded as the sealed book of human life. I said the theory was highly defected then; now it seems to me even a pseudoscience. Actually, the term “pseudoscience” is not proposed by me, but those who made up false sciences. As is known, Watson is not only a great life scientist, but the first leader of human genome group, and more importantly the Nobel Prize winner.

Since 1953, a total of 47 Nobel Prize awards have been granted in terms of genetic molecular biology. Nobel Prize is great to us, but why? Because people have been sensationalizing relevant studies around it and it was raised up to a climax eventually. In fact, they are telling a lie, and now the truth has been uncovered half a century. It was just when I was going to reveal the truth by suing Nobel Prize Assembly the father of genetics told the truth ahead of us. Certainly, not all of the 47 prizes are false, and some of them highlighted the progress made in physiological studies. After all, what a power it is to push human life science i.e. modern medicine to the top, and name it as cutting-edge study of life science.

At the end of 20th century when people realized they could not make any progress on genetic study, they transferred their focus to embryonic stem cell study. The concept of human development began to be proposed for study. They speculated since egg-sperm binding can develop a human body, separating a cell from the early-stage embryo can generate a new human body, and cells separated at a later stage could possibly develop into arms or legs. That is the ideology of embryonic stem cells. What is an embryo? It is the zygote formed by egg-sperm binding. The study was then taken around this system. However, the human development is a natural potential of humans since their appearance on earth. Scientists played a tricky game by polishing it with more sophisticated names such as totipotent stem cells, pluripotent stem cells, etc. That is how the concept and ideology of stem cells popped out. Nevertheless, humans have been passing on generation by generation smoothly before the stem cell concept. Now scientists intentionally go around the egg and sperm of totipotent potential to develop into a human, and instead contribute the totipotential to embryonic stem cells and pluripotent cells. The entire world has been crazy about those new concepts. Stem cells has become the equivalent term of high-tech. As a matter of fact, it is just the name that was changed. The new name originated from the discovery of cells in haemopoietic system, where hemapoietic cells was found able to turn into red blood cells and some other types of cells from primitive stem cell status. Since then, this concept was adopted in the study on embryonic development by Americans. They were listed at the first of top ten major news published by Science in 1998 when our study results were released simultaneously. Because they were made up by scientists, our in situ stem cell study has been referred by the public ever since. As we claimed before, their concept was whimsical, for cultivating natural cells in vitro was impossible and human cells would change in their property when separated from the body, which has been a conclusion by our study in our attempt to identify Keratin type 19 stem cells on human wound. During our study, we made no progress in our finding of K-19 within five years when two grades of PhD graduations involved were accomplished. I told PekingUnionMedicalCollege, our collaborating research center that their modern method of identification seemed not helpful and I was going to try my “receipt”. After that, I went to Nashi Affiliated Hospital of Henan University with Prof. Zenglu Xu, key member of my team, where we took the biopsy from the skin wound, preserved the sample with liquid Nitrogen container and directly returned to our lab for cytological examination without further cultivating the sample cells so as to avoid any unexpected change during the cultivation. Consequently, we found the K-19 stem cells in it. Since then, we could follow and observe the behavior of the K-19 stem cells in vitro.

The study of embryonic stem cells, even though there is no ethical issue, can achieve nothing. In the published paper last year by Shinya Yamanaka who won the Nobel Prize cited our saying that human can’t cultivate natural pluripotent stem cells, that is, embryonic stem cells is not pluripotent stem cells, but he didn’t tell the public he cited our saying. As said by XU Rong-xiang in 2002 any cultivated cells are man-made ones. He keeps his eyes on my studies and says what I say without mentioning me. His iPS cells are the analog of pluripotent stem cells rather than pluripotent stem cells. By saying this, I would like to point out there are two cutting-edge technologies, one is the genetic molecular biology and the other is embryonic stem cells. Those reproductive cloning researches are the derivatives, and those so-called scientists make use of cloning technology in order to obtain stem cells. Cloning actually is to change the nucleus of an egg, i.e., actually, the transfer of genetic material. So what are the outcomes of reproductive cloning? Of course, it is of no value.

In 2007, the father of cloning technology gave up his technology while the studies of embryonic stem cell have not yet stopped. But there exists a very serious ethical problem of embryonic stem cells in that a real embryonic stem cell has to be obtained from an organism, that is, to save someone by killing someone else in terms of ethics. What is the concept of being a human? An egg and a sperm combine together to develop into an embryo which develops and matures in the womb of its female parent. Any behavior that damages the embryo is one of murdering.

It has been proved by facts that the means of saving diseases by killing life are unacceptable, which not only involves the ethnical issue but is impossible from the perspective of science. Up to now, all the so-called test-tube babies are fake ones since they are only inoculated in tubes and they aren’t cultivated in tubes. The day before yesterday, the father of test-tube baby died, which marks the end of test-tube history.

The naming of test-tube baby is more counterfeited than that of iPS cells because a baby can’t be cultivated inside a test tube. So-called test-tube baby to be specific should refer to the pre-embryonic period of a baby and be named in vitro inoculation embryo. But the whole world calls it test-tube baby. If someone is able to cultivate a baby in vitro, he would be prosecuted, just like our case of prosecuting the Nobel committee.

With the self denial of Watson on gene therapy, human history becomes pretty clear. Of course from the point of view of scientific exploration, the previous studies on gene therapy are of value since in the invention and discovery process of human, exploration is inevitable and necessary. However, when the exploration has been proved to be of no real searching value, continuous hype is abnormal. All the hypes and studies on the genetic molecular biology are based on Watson’s theory. Though some people developed his theory, as Watson has denied his theory, the followed studies have no meanings at all. Thus, we say Watson’s self-denial is the end of the human cutting-edge life science of genetic molecular biology. What does the end symbolize? It symbolizes the period from the age of ancient Greece Hippocrates two thousand five hundred years ago to now is still the era of modern medical science. The medical problems that should be solved by cutting-edge life science remain unsolved, that is to say, the human medicine as the mainstream of human life science still remain in the era of traditional era, i.e. making use of natural or chemical substance to attack diseases, while no achievement has been realized for human life itself.

Today, there is no radical and thorough denial of gene therapy study of all kinds. There are still some scientists upholding it and how misleading they are! However, the following days will witness the gradual elimination of the influences of the human cutting-edge science lasting for about half a century.

Medical science up to now has not made any progress. Genetic molecular biology as a mainstream and embryonic stem cells are only a sideshow of human medical science. We hope that human diseases can be cured in the era of medical science during which surgery progressed rapidly from radical surgery to minimally invasive treatment, in combination with some modern technologies. But minimally invasive surgery is the same as the surgical operation in mechanism in that both are to remove the abnormal tissue away using surgical methods. The “progress” of the modern scientific technology is in the price of losing tissues for life. Generally, in such case, a natural substance and a surgical technique are involved. In the future, it will be impossible for the government to fund you to do such meaningless work and of course, the current situation may have to last for quite a long time.

As we all know, whether a science is successful or not depends on its scientific outcomes. However, for a half a century, there are so many academicians who are reviewed by or through hyping concepts, signing name to support research projects without meanings, publishing papers with no actual research results in scientific journals with high impact factor, and to the end, they engaged science produced nothing. How would their grandchildren, great-grandchildren think of them? Maybe, they would be called liar.

Therefore, what spirit should we adhere to? From the ancient times to the modern era of life science, the scientific system of Hippocrates has no come to an end and it is making progresses with the development of history of some progress, but it can still not solve the problem of human organ diseases. That is to say, human disease can only be treated symptomatically without being treated radically. Some big pharmaceutical factories and hospitals are actually performing the symptomatic treatments, which, of course, is of importance. For example, a critically ill patient with coronary heart disease, after receiving surgical treatment to dredge the blood vessels, he can survive for a longer time, but the coronary heart disease itself has not been cured. From a scientific point of view, how to eradicate a disease is a problem medicine should solve.

3. New Era of Human Body Regenerative Restoration Science ----- The Promising Future

Highlight:

The human body regenerative restoration science established by Professor RongXiang Xu is a totally new branch of science studying the body's innate regenerative potential of human body cells and regenerative nutrients. It is a comprehensive new system in life science which utilizes human body regenerative potentiality and exogenous regenerative nutrients to achieve regenerative restoration of tissues and organs in situ for acquired defects, premature aging, mutation, severe diseases and premature apoptosis of the human body. Its core scientific technique is the 'In Situ Human Body Regenerative Nutrient Cultivation Technology' involving 'Induction of Stem Cells from Somatic Cells' and then 'Regenerative Restoration of Tissues and Organs In Situ'.

The rise of body regenerative restoration science will bring four human revolutions and the human will enjoy totally new scientific system of health protection: human life science revolution, agricultural revolution; food industrial revolution and human life energy revolution. This is a big change for the world as it has entered a new era --- human life-regeneration.

What is the future of medicine? The future of medicine looks towards the medical use of drugs and surgery to treat diseases. As Watson said he still believed in searching for the fundamental of treating diseases on good chemistry. We will never deny this point but agree. Natural substances and chemicals have been aimed at treating diseases and the 2500 year practice has proved to be effective, but the disease is not to be cured- it only reduced the pain. This is true and also undeniable. There is also a bad conclusion that Western medical treatment using chemical drugs is summarized as harm greater than benefit. From a long-term point of view, the safety issue of chemical drugs to mankind is one of the biggest risks. Some large pharmaceutical factories do not dare to research and develop new chemical drugs. If safety problems occur, the factories may become bankrupt, resulting in stagnant research on chemical drugs. But in accordance with the law, not all chemical drugs are harmful. That is, if the study is performed accurately, people will not be harmed. Of course, we do not have this ability, because we are not studying this content.

What is the future of medicine? Future will be in two directions, one is going towards more heavily physiological-based research, and using physiological research to cure diseases. This road is not based on guesses but based on logical analysis as it is only when we approach close to physiology that the toxicity is minimal. Under the physiological premise, we can treat diseases with minimum toxicity. 2500 years can confirm that chemical medicine is effective against diseases, which is only right and proper fact proven for a long time—this is the future medicine.

Human Life Science has formed a new system of the future! Human Body Regenerative Restoration Science is the science of future human life security, life support and long-life. We should not replace medicine and we cannot replace medicine. Then what is the concept of Human Body Regenerative Restoration Science that we speak about? Whether it’s plagiarism of history or pure invention, whether it is technologically promoted or lectured in class, we must uphold the principle and be clear of what kind of science we represent. Our science is not medical science using natural and chemical substances for curing diseases. If we do use ourselves to cure diseases, we are worthy progeny of Hippocrates. We are the first one of a kind of discoverers in human history to promote human life and health, not only to eliminate diseases, but also to promote human health and longevity. What is the original concept of longevity? It is not to attain a disease. I have said that saving someone from coronary heart disease and saving the organ's health and achieving the continuation of life. The disease and medical goal are the same, but the methods are different. The continuation of life of human organs and systemic continuation of life exists only in history as a dream, there is no reality. There is only a dream but no real research. Of course, we cannot deny the existence of some research, such as the study of gene to extend life, claimed by a wide variety of people, today called nausea genes, as well as headache genes, etc. There are claims of discovering human longevity genes; like the stars in the universe, a star named Zhang could be called Li, with nothing ever being resolved because we do not know how many as it’s just a label.

The conclusion of our study, is only our journey from the beginning to the end, in reality, we are just taking a "shortcut" (not misled by those cutting-edge concept) because it is a new route, a divine order to let us complete this "task". Human burn treatment has existed for tens of thousands of years. Starting from the treatment of burns 30 years ago, God has given us the model, and if we did not proceed from the perspective of life science of wound healing, we cannot imagine if there would be a future.

Our science is not based on treating the disease itself. For instance we do not treat a man's inflamed appendix by removal of the appendix and treat its acute gastroenteritis with antibiotics. We provide you full nutrients and make your body healthy and resistant to diseases, that is, changing the diseased cells. The reason is simple, providing full nutrition to our own cells and developing regeneration potential to cure diseases through the four main channels to death which human medicine cannot yet solve. Many series of diseases are caused by fibrosis of aging cells so we use new cells to replace those cells diseased from cell fibrosis, including premature aging of organs due to fibrosis. We use newborn cells to replace diseased cells, apoptosis-deficient cells and malignant mutated cells. Of course, this replacement is not a simple mechanism. If the old is not gone, the new will not come. Trauma is a supplement of defect. Ulcer is defect plus replacement. Human organs also have this internal mechanism. When cells are regenerated, they replace the older cells as this is the regeneration mechanism of human body, which not only activates cells but also develops the entire organ system. The body's regenerative restoration mechanism replaces sick organ cells so that health, reversing age, normalizing mutation and cancer, reducing withering and compensating normal cells are achieved, then maintaining the body's organs healthy without sickness or curing the diseases. This mechanism is now proved to be true.

Since the prosecution to the Nobel Prize Committee, we let PR Newswire electronically track us and there are a number of viewers concerned about the Human Body Regenerative Restoration Science and patents. How much? One hundred sixty million impression. Human Body Regenerative Restoration Science at that instant had become known by the prominent people in the world as a hot topic. What was the response? Newswire reported that: We do not deny it is very rare. Only Scientist magazine cited denials, but then I finally found in Barcelona, Spain, a self-called stem cell expert who put forward his opinions. What did he have to say? He said Xu R.’s patent of the white type 19 stem cell is not a stem cell marker, not knowing when the actual stem cell marker is not Xu R.’s invention but rather research done and recognized by the branch of science examining the physiology of human embryonic science. For your information, the earliest embryonic stem cells of human skin called keratin type 19, whether it is 19 or type 16 type 15 type 10, are all stem cell markers. This is not controversial! How could it not be a stem cell marker, this was confirmed early on by human stem cells. This is knowledge on university textbook. (This self-claimed stem cell scientist may be illegitimate).

Why for popular science is the era of human body regenerative life science not coming but has already entered? Those who do not understand human body regenerative restoration science are ignorant and do not know science because it is at the forefront of the field, and is to replace medical treatment, including these three systems: Watson’s genetic and molecular biological systems, Thomas’s embryonic stem cells, Xu R.’s somatic cells and stem cells system.

In 2001, we identified somatic and stem cells, which are at the core of Human Body Regenerative Restoration Science. In 2006 inJapan, Shinya Yamanaka published iPS cells, stem cells known as somatic cell transfer system; our research direction is the same, but now Shinya Yamanaka claims to not have cloned stem cells and this will provoke major problems. Originally the somatic-turned stem cells were called Xu R., he said I am also using Xu R.’s somatic-turned stem cells, which brings up the problem of imitation as his scientific method is completely different. His is transferring genes, a system negated by Watson as any genetically modified treatment is impossible to succeed as new species are unable to grow in situ of the original species-- cardiac allografts reject transplants, and the cell is the same, cancer cells are variants of normal cells and this is common sense in science. So at the forefront of science in accordance with these three systems, what only remains is our research on somatic-converted stem cells. This is basic research as I have not explained our application of research, but our research is based on the idea of somatic-turned stem cells to achieve organizational applications, while Yamanaka has not yet truly found stem cells. So at the forefront of advancement in research on Human Body Regenerative Restoration Science, our research is the only one on stage. Before Watson made his discovery (negating gene therapy research), scientists held an unrealistic dream that through gene therapy we could solve disease, but according to Watson's original words, at the present not even one disease had been resolved with such a method, and it wasn’t until he had cancer that he realized he had also been eyeing this research topic covetously. The first human gene molecular biology research on cancer was established by him and the United States government invested one hundred and twenty million U.S. dollars in establishing prestigious research universities in the world; with research institutes focused on studying embryonic stem cells and establishing gene molecular bio-chemistry laboratories springing up like mushrooms. All those who engaged in genetic and molecular biology suddenly became chief researchers. A percentage of the GDP of the United States was invested in this, yet after more than half a century, found they invested in the wrong areas, and yet had already invested hundreds of billions of dollars. Now we are the only ones on the world stage, and deeply seeking understanding from everyone to understand that we use quality technology, yet people do not understand and underestimate our potential as diamonds in the rough as value-less glass. Why? Because the expanse of genetic and molecular biology is too large, there are too many people who believe in scams and do not believe us. This is the mainstream trend of humans, with publications and news organizations reporting only on others’ research. Once the Human Body Regenerative Restoration Science proposes a theory, there is controversy. In fact, those are all liars, we possess results. Now that era has passed, the forefather of molecular genetics says you are wrong.

Medical science is an accumulation of tens of thousands of years of lessons learned based on the life of the human body and human life science greatly looks towards Regenerative restoration science. The next stage of human life sciences should be diversified, and yet has turned out to be unified with medical science, medicine, chemistry. What is it now? Without the use of chemical drugs to combat the disease, we indirectly eliminate the disease and directly leads to the longevity of life, and we use this simple analogy for everyone to understand Human Body Regenerative Restoration Science.

Traditional medicine is the direct fight against the disease, whether patients can survive with their original cells is not relevant, cells are only given a hormonal boost. However this hormonal boost will in fact leave behind residual problems. If medicine were to use natural substances to fight the disease, it still depends fully on human life.

Hospital can never give you longevity, all methodology is based on surgery and the removal of organs in exchange for the sustainment of life. We adopt the same mechanism of allowing the continuation of human life and yet we use an indirect method where we can ensure the safety of human life, with a direct method of the continuation of human life. Everyone must be aware of this truth that this is the essence of Human Body Regenerative Restoration Science and innately cannot be mixed together. If mixed together, it becomes pseudo-science. For instance, MEBO wound ointment’s role in wound treatment and original medical treatment are completely different, with ours promoting self-regeneration of life and an environment for the growth of cells, using the removal of the bad cells to promote good cell re-growth.

From now on we require that the basis of our clinical research must be clear, if not, you clearly cannot be experts, and others will say that you are pseudo-science. At any time, speak the truth and even if it sounds unacceptable, it is the truth. Human Body Regenerative Restoration Science and medicine are two completely different scientific systems, we have already made clear that human body regenerative restoration science is neither Eastern medicine nor Western medicine, as we use natural substances. Medicine is to find substances with effects on disease. We are looking for the nutrients spectrum for potential regenerative cells' activation, as well as cell division, proliferation and differentiation. MEBO wound ointment is such an amazing medium as it contains substances to ensure nutrition for cell regeneration.

In 2002, some academicians questioned these ingredients were proteins or fatty acids, I said neither amino acids nor fatty acid, he said that is not possible, I said it is. In short, I said that the substances you are aware of do not have regenerative properties or there would be no need for me to make these discoveries. He said how did you figure it out, and I explained that it was quite simple that in fact the substances were part of the ingredients of the burn wounds treatment and could be cracked and extracted. That year after Sun Xia and I spoke at StanfordUniversity, he asked me to visit their hospital in the Surgical Research Laboratory of "MEBO", which is funded by the national government, was set up for 15 years in order to reproduce the substance in MEBO ointment. I said that if your country has money, then go ahead and look for it, but if you had told us earlier, we could have provided guidance as to the regenerative properties of MEBO, instructions that God gave me. It originates from natural environmental conditions and is a future significant "renewable source of life." Later we went to Manchester, England, entering the house of my friend, we saw "Chinese Journal of Burns Wounds & Ulcers" placed on the shelf, and had a China Academy of Traditional Chinese Medicine postdoctoral specialize in translating my article. This all indicates that regenerative science deserves great attention as it has great importance in the area of renewable life sciences. If you do not believe this fact, just do the scientific research.

The human regeneration life sciences era has come upon the life science community, and there is no one more capable of this research than us. To wait 20 years later, these gurus will be old, and new scientists will begin to appear to accept new things. But just because the idea does not shift, does not mean it should not come.

Some people are confused, as when we published our research in 2002 regarding tissues and organs, some academicians exclaimed that it was different from the concept of modern medicine. I said it couldnot be the same; otherwise it would be a big trouble. If you call it the same, I would be making no progress. The association of organs is a function of cells in tissue, but my research on tissues and organs is used to select regenerative substances that people can consume in order to have an effect on the human body, which are two different concepts. It was stated clearly at the conference but the results the next day were reported that the cloning of human organs is impossible. They imagined that cells would be used to clone an organ transplant. What decade is this? For a newborn baby's heart to be transplanted into a 50-year-old is a joke. Therefore, a world-renowned US university’s Institute of Regenerative Medicine have been making efforts to reproduce myocardial tissue culture and have invited me to visit, implying this recognition of our branch of science as important. We also acknowledge their research, called tissue engineering, where tissue is biodegraded materials in the human body bracket, put a tissue cell culture, but progress is hard to make. Of course, if we cooperate together, we may achieve progress, however, we believe that the practice of cultured tissues and organs is of great research value but not of great practical value. We have explored body regeneration in vitro for more than 30 years to find the ideal destination, humans have experienced 2500 years of scientific history of modern medicine and there is still not a technology that can cure disease of human organs disease cure-- only symptomatic treatments. Our greatness is not in success, but rather for establishing the basis of scientific research.

From now on, we will be the basis of all past scientific research and illuminate the world with our development in science and be leaders in this research. I spoke in the past about planning, this plan is now to become a reality because Human Body Regenerative Restoration Science will not only be able to indirectly target organ disease but its greatest contribution will be to prevent organ disease and prolong life expectancy. This is an achievement in the life sciences, and under this premise, human body regenerative restoration science will become a mainstream development of a new era of human development. What is this new world? From the history of the development of human civilization to the present, every major change will bring to rapid social development. For instance, the first industrial revolution revolutionized manual labor into mechanization, with decades of development turning simple human labor to mechanical labor, so that the whole world fundamentally changed. The West developed rapidly. The Second Industrial Revolution rose to modern machinery with the development of the internal combustion engine from the original steam engine, and also the development of electricity, leading to advancements in telecommunications.

We represent a more comprehensive revolution, not a revolution in medicine, but rather a guarantee of treatment of disease and prolonging of life. For instance, specifically in revolutionizing burns, because traditional burn therapy did not treat burns but rather cutting off burned tissue, this only created additional surgical wounds. This is not burn treatment, so we need to revolutionize this way of treatment.

Our Human Body Regenerative Restoration Science will bring four human revolutions. Human Body Regenerative Restoration Science will establish a new system to guarantee and prolong health. Humans will be able to benefit from this new scientific body of health protection, in which big changes will be made and a new era will be opened. This a great revolution of human life science, the starting stage of the four revolution aspects.

The second revolutionary aspect is revolutionizing agriculture in human history. From ancient times to modern times, fish would be caught and baked to eat, rabbits would be caught and barbecued, whole lambs would be roasted. This is the timeless standard of eating and although a few pieces of cutlery have been added to the modern eating table, the ancient original way of eating has not faded. The process of how food we eat turns into nutrients that sustains life and the process of how food is digested by our gastrointestinal digestive function are important to know. It takes 70% of the stored energy in your body to digest a meal. Secondly, the gastrointestinal absorption function of the system correlates with age as a 50-year-old will absorb half of a pound of food while an 80-year-old will eat a meal and only absorb 20 % and excrete 80% wastage. Third, other components of our body will require synthesis of our cells, which needs to consume much of your energy. Human Body Regenerative Restoration Science can revolutionize agriculture as human regenerative cell activation and nutrition lineage can instigate regeneration and produce new cells to replace those sick, aging cells, promoting health and longevity. This is the answer: consume regenerative cells that have nutrients activation which will reproduce new cells and replace those bad cells, resulting in age reversal and, normalization of organs. This is the simplest explanation.

Human Body Regenerative Restoration Science's program is very simple: people have two lives, basic life and regenerative life. Regeneration of life needs regenerative nutrition while the original life needs to be transformed. We cannot continue to eat the food of the ancient times, our first reform is to change our diet as the core of human regeneration is to maintain an effective intake of nutrients. Your body naturally changes, as long as the meals at home are changed, all will change. Human Body Regenerative Restoration Science had already achieved the means to ensure life extension, once world agriculture is revolutionized, all changes will be made in guaranteeing longevity. If we reform the method of growing crops and go according to certain guidelines, calculating which plants should be planted, which plants should be planted, which chickens, ducks, pigs should be cared for. Although both of the two industrial revolutions did make some impact on agriculture, the United States is a large consumer of poultry and Europe still consumes large pieces of steak, lamb chops like the ancient times, we need to revolutionize agriculture and material production.

Thirdly, to produce industrial revolution, industrial labor, transportation, communications were all reformed. What about now? It is revolutionizing the industry of life. When it comes to wine making, the steps are taken through a county’s brewing field, the next step may be a township’s large joint food processing plants. To process food into a loaf of bread, cakes, we processed what? "Nutritionally complete Milk ingredients ", or" full of nutrients drinks, all physical processing, no chemical processing. For the first food industrial revolution, it is necessary to liberate 50 percent of the energy in your body.

The second program is gastrointestinal, reversing the age of gastrointestines as an 80-year-old can become a 30 years old if the amount of food stored can save energy.

Third program is regarding the human body's common components. If we use 2000 Kcal units of energy output as an example, we could screen 1900 units of energy for synthesis in vitro to lessen energy consumption so that the total energy of the human body's average daily consumption of 2000 calories is reduced to 700 calories. The amount of food available for consumption can feed three times the amount of current population of the Earth, and this could produce health and longevity.

Next, the agricultural and industrial revolution needs the government of each country to reform meals so that they include reproductive nutrients mixed together. This will move the industrial revolution along by creating a new renewable energy sources.

The fourth is the human life energy revolution. Creating life energy is comparable more important than oil or electricity as what humans need for life extension is required by all to achieve the regeneration of life sciences. An example is that me and my friend of the same age-he is now a minister- were talking and I told him that when you keep up with regenerative restoration, if you do not keep up, and you have to keep up now in compensation of the past few years. While talking, we were standing together to let the waiter evaluate which one of us was older and the waiter said that my friend was this year a little more than 60, while I was a little over 50. I said that the waiter was quite polite saying my friend was a little over 60 and I said he looked 70, too old. I said to the waiter that the two of us were the same age, and he was dumbfounded. People get cancer and die early two years, changing their households, but people know that preventing premature death is not a life-saving straw. The future of Human life is a fight against these premature deaths and is a heavily economic-based competition.

Four revolutions led to the change of the entire human world in terms of politics, economics, and socially. People who are not dying should be making plans to sustain health. These four revolutions will usher a complete revolution of society, whichever president of a country that does not keep up with the trend is considered failing his duties. It was never realized the Rwanda became one of the first countries to keep up with revolution, because of the country’s state of poverty. The country’s leadership was not concerned with maintaining longevity but rather just to be able to have each mouth fed. Now we are faced with four environmentally-friendly energy revolutions for revolutionizing human life as machinery does not require the use of chemicals anymore as a combination of natural substances, like a cocktail of natural milk formula can be milk not just for children but for all of mankind to consume nutritionally as humans do not need too much energy. In the future world, the scientific revolution for the human reproduction of life is a force that cannot be stopped by anyone and this current era of science is the defining stage. The next step is to ask governments to promote this as a business as groups of companies can be useless, the beginning of this technology should be held confidential under government secrecy. Xu R. will surely contribute to producing a renewable source that will activate the regeneration process as the regeneration process requires cell activation as solely providing regenerative is useless to the process. Drinking Elixir (MBEO regenerative nutrients) will only cause high cholesterol as only regenerative cells can use and consumption it. So humans need to control reproduction of the cell activator, which will be the key defining target of research and analysis. Moist exposed burn ointment (MEBO) contains this activator, and can thus regenerate the skin. The key is within cell activation and organs can only be regenerated if there is a regeneration activator. This activator is more precious than that of gold, this is key to the regeneration of life, the key to regeneration of life is in our hands and can be a key benefit of the peoples of the world. Of course, China as my own nation, should also exceed in striving for these benefits, just sketching the future of the world is very simple, but launching this effort to produce these renewable energy sources are our key goals.

Our lives include two renewable life mechanisms, one is the basic life and the other is the renewable raw life energy, this energy source will be combined into one, as new renewable energy is nutrition like milk Powder. This concept will give the whole world change, change for the better, such as the electronic technology revolution like American company "Apple", and we will all enjoy a stable global economy. The technology of World War II was led by the history of the First World War and its handicraft mechanization, while in World War II, workers modernized the industry. We believe that the electronic revolution will lead to World War again, but the life science revolution will produce so much energy that people can live longer, produce energy as a global source so that it can be re-allocated anywhere and provide growth suitable for solving the food problem. Who is going to command it? Do not know. So we want to lead humanity through each process in the development of civilization. Every aspect is very simple, leading to human health, human security, longevity, while no longer having to worry about dinner. A better future will be eternal because it is the history of mankind. The fact cannot be buried that the body's potential for regenerative cells is activated after using this power. After the diet reform, people will have changed, society will changed, investment of provinces engaged in economic construction that is used in the environment will change the condition of human lives forever.

Life science can only cure a small part of the scientific system but it will bring a whole change of life in regards to human regeneration. If we do not get sick, doctors may also take a break. The Human Body Regenerative Restoration Science is trending into the mainstream, and it is inevitable.

Epilogue

I speak today of three parts, first to understand our perspective of scientific knowledge of the life sciences until to the stage of modern scientific medicine, Hippocrates to present. From the middle of the last century with the beginnings of genetic helix molecular biology, all of a sudden it has become the mainstream in human education yet while in the scientific mainstream, there is trouble as the state plans to stop it. Scientific change will bring about regime change. In the new regenerative science sector, we have our standards and will build the foundation. Human Body Regenerative Restoration Science must be separated from the field of medicine. We are not belittling medicine nor denying medicine as the foundation, but we are not medical. Medicine can be natural to combat disease, and it is with nutrients that the regeneration of new cells can replace diseased cells, helping the body to fight the disease. This substance is not against disease, but based on the life of the body cell life which requires the most appropriate nutrients. There are two types of this nutrient, in situ activation of cell nutrients and the other is training in situ cell nutrients. There are two types of cultured cells: one is regenerated and the other is original. Culturing a cell for regenerating a new cell is the core mechanism of Human Body Regenerative Restoration Science.

Human Body Regenerative Restoration Science will bring humanity four revolutions: the scientific revolution of human life, agriculture Industrial Revolution, food industrial revolution, and life energy revolution. It will lead us entering the brand new human regenerative life world.

I hope humankind will lay the ideological foundations of human regenerative life world, and set a good outlook on life. We should each in our own positions make a great contribution.

Human Social Project: Cracking the real code of life